Fire crews reported the fire on multiple floors of the Duxbury House Thursday morning.
The two-alarm fire started around 10 a.m.
Duxbury Fire Chief Kevin Nord said the fire was most likely weather-related.
The state fire rehab truck was on the scene of the fire around 11:30 a.m.
More information will be provided as it becomes available.
Route 53 will remain closed for at least an hour while emergency crews deal with the fire.